Linked Life Data

669819

Source:http://linkedlifedata.com/resource/pubmed/id/669819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-9-30
pubmed:abstractText
The Hong Kong/68-ts-1[E] virus and its Udorn/72 and Georgia/74 recombinants, which have a 38 degrees C shutoff temperature and a ts lesion(s) on the genes coding for the P3 and NP proteins, were adequately attenuated and immunogenic in adult volunteers who lacked serum hemagglutination-inhibiting antibody (titer, </=1:8), but who possessed serum neuraminidase-inhibiting antibody. Two Victoria/75-ts-1[E] clones that also had a 38 degrees C shutoff temperature and a ts lesion(s) on the same two genes were administered to adult volunteers who lacked both serum hemagglutination-inhibiting antibody (titer, </=1:8) and neuraminidase-inhibiting antibody (titer, </=1:4). In contrast to the behavior of the earlier ts-1[E] recombinants, the Vic/75-ts-1[E] recombinants retained the capacity to cause febrile, systemic illness. However, the recombinants were attenuated compared with wild-type virus. The Vic/75-ts-1[E] virus vaccinees shed a larger amount of virus for a longer time than the previous ts-1[E] vaccinees, but they shed less virus than volunteers infected with wild-type virus. The ts-1[E] virus shed retained its ts phenotype in most instances and failed to spread to susceptible contacts. Vaccinees were partially protected against homologous wild-type virus challenge. The failure of HK/68, Udorn/72, and Georgia/74 ts-1[E] vaccinees to develop systemic reactions may reflect the presence of neuraminidase immunity before infection. In this situation, attenuation probably resulted from the degree of defectiveness of the ts-1[E] recombinant virus and the existence of neuraminidase immunity in the recipients. The 50% human infectious dose of the Vic/75 ts-1[E] virus was less than 10(5.2) 50% tissue culture infective doses. This suggests that at the time of a pandemic shift involving both the hemagglutinin and neuraminidase glycoproteins, a small amount of live virus vaccine might be effective in initiating infection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-1003014, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-1083310, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-1272630, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-14310573, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-4541685, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-4626544, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-4743544, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-5000515, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-5027388, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-5111887, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-669818, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-810557, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-860398, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-886200, http://linkedlifedata.com/resource/pubmed/commentcorrection/669819-894078
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
671-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Temperature-sensitive mutants of influenza A virus: evaluation of A/Victoria/3/75-ts-1[E] recombinant viruses in volunteers.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.