Linked Life Data

6696827

Source:http://linkedlifedata.com/resource/pubmed/id/6696827

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-4-24
pubmed:abstractText
Many defects in macrophage functions in dengue type 2 virus (DV) infection have been shown to be mediated by production of the virus-induced cytotoxic factor (CF). An attempt has been made to determine whether the alterations in Fc-mediated functions of macrophages in DV-infected mice are due to CF. Mice given CF intravenously show a rapid fall in total numbers of peritoneal and spleen cells. The number of cells in the peritoneal cavity recovered in 48 h. but recovery in the spleen was not significant. The capacity of the splenic and peritoneal macrophages to attach and ingest opsonized sheep erythrocytes was significantly reduced, the lowest values of attachment index (AI) and phagocytic index (PI) being observed within 2-3 h. At later periods the AI values increased markedly but the PI values remained depressed. The effect was dose-dependent. The effect on Fc-receptor functions of macrophages in DV-infected mice thus appears to be mediated through CF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1021
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effect of dengue virus-induced cytotoxic factor on Fc-receptor functions of mouse macrophages.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't