Linked Life Data

6696463

Source:http://linkedlifedata.com/resource/pubmed/id/6696463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-3-12
pubmed:abstractText
Pharmacokinetic behaviors of human fibroblast interferon (HuIFN-beta) administered intravenously to rats were examined. After intravenous injection, plasma interferon level decreased in a biexponential fashion having the half-times of 15 min and 120 min respectively. Distribution levels of HuIFN-beta in the tissues at 30 min, though the actual concentrations were less than that of plasma, were observed according to the following order; kidney greater than adrenal greater than lung greater than spleen greater than liver greater than testis. Small amounts of HuIFN-beta were also detected in the thoracic lymph and bile but no HuIFN-beta was found in urine. The in vitro study indicated that the stability of HuIFN-beta was different in each tissue homogenates and body fluids. From the results obtained, we concluded that HuIFN-beta exhibited a low distributional character to the tissues when administered intravenously. It was also suggested that the kidney and the liver were the main catabolic sites of HuIFN-beta.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
[Pharmacokinetics of human fibroblast interferon in rats].
pubmed:publicationType
Journal Article, English Abstract