Linked Life Data

6696110

Source:http://linkedlifedata.com/resource/pubmed/id/6696110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1984-3-16
pubmed:abstractText
The prevalence, amplitude, and latency periods of "on," "off," and "intermediate" contractions in response to transmural stimulation were recorded in transverse rings of circular muscle from different levels of the opossum esophagus. Ten-second train stimuli consistently produced off contractions. On contractions were not seen at lower stimulus frequencies (2 and 5 Hz); however, their incidence approached 90% at higher frequencies (40 Hz). Intermediate contractions occurred only at stimulus frequencies of 10 Hz or greater and were less frequent than on contractions. In general, the on and intermediate contractions had significantly lower amplitudes than the off contraction. The on contraction occurred with a latency period from initiation of the stimulus. This latency was greater in the more distal sites and decreased with increasing stimulus frequency. The off contractions occurred with a latency period from termination of the stimulus. This latency was not dependent on either stimulus frequency or site along the esophagus. Atropine antagonized the on and intermediate contractions but had no such effect on the off contraction. Tetrodotoxin abolished the on, off, and intermediate contractions. This study suggests that an intramural mechanism exists that upon stimulation produces atropine-sensitive on contractions. These contractions may play a role in esophageal peristalsis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
246
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G137-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Characteristics of "on" and "off" contractions in esophageal circular muscle in vitro.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.