Linked Life Data

6695816

Source:http://linkedlifedata.com/resource/pubmed/id/6695816

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-3-22
pubmed:abstractText
Preliminary clinical experience indicates that flecainide is a useful antiarrhythmic agent for the suppression of spontaneous ventricular arrhythmias. The drug also exerts marked effects on accessory atrioventricular (AV) pathway and retrograde fast AV nodal pathway refractoriness, and therefore may be effective in treatment and prevention of reentrant supraventricular tachycardias. Electrophysiologic studies indicate that flecainide slows atrial, AV nodal, His-Purkinje and intraventricular conduction and, to a far lesser degree, prolongs refractory periods in these tissues. The effect of the drug in slowing conduction within the His-Purkinje system is particularly marked and is commonly associated with prolongation of the HV interval beyond the normal range. Flecainide causes a small but significant increase in the QT interval duration, which results largely from prolongation of the QRS interval. Significant prolongation of the sinus node recovery time has been observed in patients with preexisting sinus node dysfunction. Available electrophysiologic data suggest that flecainide should not be administered to patients with advanced disease of the His-Purkinje system or sinus node. The safety of the drug in patients with mild to moderate abnormalities of His-Purkinje conduction or sinus node function awaits further study.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
26B-29B
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Electrophysiologic properties of flecainide acetate.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.