Linked Life Data

6695161

Source:http://linkedlifedata.com/resource/pubmed/id/6695161

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-3-23
pubmed:abstractText
The pharmacokinetics of phenytoin are studied in 2 patients on CAPD treatment. Free and protein bound phenytoin are lost in the dialysate. The peritoneal clearance of phenytoin varies from 1.6 to 2.4 ml/min. The peritoneal mass transfer varies from 0.022 to 0.059 mumol/min, depending on the phenytoin dose given. The dialysate concentrations of phenytoin reach 40% of the serum levels. Peritoneal losses of phenytoin may be 5% of the daily intake. The clinical significance of serum level measurements in monitoring of phenytoin therapy is discussed. Beside clinical symptoms, the serum free phenytoin level is of most importance. In uremic patients the albumin-bound fraction of phenytoin is reduced.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0036-7672
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
16-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
[Pharmacokinetics of phenytoin in continuous ambulatory peritoneal dialysis. 2 cases and brief review of the literature].
pubmed:publicationType
Journal Article, English Abstract, Case Reports, Research Support, Non-U.S. Gov't