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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1984-3-12
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pubmed:abstractText |
We report a 2 10/12-yr-old girl with precocious pseudopuberty due to a feminizing adrenal carcinoma without Cushing's syndrome. The patient had marked elevation of plasma concentrations of the delta 5 adrenal steroids dehydroepiandosterone and dehydroepiandrosterone sulfate and increased levels of androstenedione, estrone, estradiol, and testosterone. Adrenal microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase 17-hydroxylase, 17,20-desmolase, and 21-hydroxylase activities in the tumor and adjacent normal adrenal gland were measured. The tumor had approximately normal levels of 17-hydroxylase and 17,20-desmolase activity, with low levels of 21-hydroxylase and 3 beta-hydroxysteroid dehydrogenase-isomerase activities. This combination of enzyme activity may explain the absence of Cushing's syndrome and the high levels of delta 5 adrenal steroids. This patient demonstrates that adrenal neoplasms arising in girls may mimic isosexual true precocious puberty and should be included in the differential diagnosis of precocious puberty.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-972X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
435-40
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6693544-Adrenal Gland Neoplasms,
pubmed-meshheading:6693544-Adrenal Glands,
pubmed-meshheading:6693544-Adrenalectomy,
pubmed-meshheading:6693544-Child, Preschool,
pubmed-meshheading:6693544-Diagnosis, Differential,
pubmed-meshheading:6693544-Female,
pubmed-meshheading:6693544-Hormones,
pubmed-meshheading:6693544-Humans,
pubmed-meshheading:6693544-Microsomes,
pubmed-meshheading:6693544-Puberty, Precocious
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pubmed:year |
1984
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pubmed:articleTitle |
Isosexual precocious pseudopuberty secondary to a feminizing adrenal tumor.
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pubmed:publicationType |
Journal Article,
Case Reports
|