Linked Life Data

6691882

Source:http://linkedlifedata.com/resource/pubmed/id/6691882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-3-6
pubmed:abstractText
In chronic bronchitis, intersubject variability in both theophylline pharmacokinetics and pharmacodynamics must be taken into account if the drug is to be used to its best advantage. Both kinds of variability can be integrated into a model which relates the steady state concentration of theophylline to simultaneously measured ventilatory response (most conveniently, the FVC). In a group of 56 patients with chronic bronchitis, the mean +/- s.d. linear response to increasing steady state concentrations of theophylline was 0.04 +/- 0.012 1 microgram-1 ml, starting from a mean +/- s.d. pretreatment FVC of 1.58 +/- 0.791. Using these population parameter values, with or without a pretreatment FVC and/or one steady state concentration -FVC observation, it was possible to predict the degree of response which would be achieved by a smaller group of 20 similar patients. These estimates were obtained using a mathematical procedure based on Bayesian Probability Theory and Maximum Likelihood Estimation. Estimates of the overall response in individual patients allowed prediction of the response at any steady state concentration. These estimates were unbiased and accurate enough for clinical use when they were based on a pretreatment FVC and/or one paired steady state concentration -FVC observation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-466923, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-678885, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-7000421, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-7032803, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-7104175, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-7153881, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-7295484, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-7310648, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-7356895, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-7431218, http://linkedlifedata.com/resource/pubmed/commentcorrection/6691882-761446
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Prediction of response to theophylline in chronic bronchitis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't