Linked Life Data

6690742

Source:http://linkedlifedata.com/resource/pubmed/id/6690742

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-2-14
pubmed:abstractText
Concentrations of doxorubicin-hydrochloride in renal interstitial fluid were compared following peripheral and intrarenal artery infusion of 2 milligrams per kilogram body weight using a diffusion chamber model. After intra-arterial application, the mean peak concentration in renal interstitial fluid was approximately 30 times higher than that after intravenous infusion (66.49 and 2.38 nanograms per milliliter respectively). After peripheral application, the concentrations in serum and renal interstitial fluid, as well as the cumulative urinary excretion, were measured until day 7 of the experiment, and the pharmacokinetic parameters were calculated. The diffusion chamber model used proved itself to be suitable for simultaneous and continuous measurement of cytostatic drug concentrations in serum and renal interstitial fluid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-5347
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Concentrations of doxorubicin in renal interstitial fluid after peripheral intravenous and intrarenal artery infusion in dogs.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't