Linked Life Data

6689677

Source:http://linkedlifedata.com/resource/pubmed/id/6689677

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-1-27
pubmed:abstractText
The metabolism and some biological properties of the N-terminal 1-17 sequence of human big gastrin (G-34) were studied during infusion in 5 human volunteers. Radioimmunoassay of the 1-17 fragment in plasma indicated rapid clearance (t1/2, 2.4 min). In doses of 75-1000 pmol X kg-1 X h-1, 1-17 G-34 did not, however, influence basal acid output or G-17-stimulated acid output. Gel filtration of plasma samples taken during the infusion indicated the presence of the 1-17 fragment of G-34, together with three other immunoreactive species. Two of these correspond to N-terminal G-34 immunoreactive forms previously found in human peripheral circulation. A fourth immunoreactive component that eluted late on Sephadex G50 was identified for the first time. This component also occurred in fasting human plasma, where it was the only detectable form of N-terminal G-34 immunoreactivity; its concentration increased during infusion of 1-17 G-34. The identification of this fragment and its concentrations in human circulation after feeding deserves further study. Because the fragments of 1-17 G-34 do not occur in antral extracts, and are not produced when G-34 or its N-terminal fragments are incubated in plasma in vitro, they are presumed to be generated from the 1-17 sequence by the action of peptidases found on capillary walls. The elucidation of the mechanisms involved is essential for an understanding of the metabolic pathways of gastrin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
86-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
N-terminal tryptic fragment of big gastrin. Metabolism and failure to influence gastrin 17-evoked acid secretion in humans.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't