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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
181
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pubmed:dateCreated |
1984-1-26
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pubmed:abstractText |
Adult male rats were treated for six weeks by prednisolone and/or 1,25-(OH)2D3 and given a diet containing either 0.5% calcium or 0.01% Ca and 0.6% phosphorus. Both prednisolone administration and a low-Ca diet were associated with a lower bone mass than that observed in control rats given a 0.5% Ca diet. The percentage of osteoid surface was decreased in rats given prednisolone; these rats also had a lower osteoclast number. The results were consistent with a lower bone turnover during prednisolone treatment. Administration of 1,25-(OH)2D3, resulting in a slightly higher mean level of 1,25-(OH)2D3 in serum, had a positive effect on bone mass, which may be related to increased osteoblastic activity; no increase in the osteoclast number occurred.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-921X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
264-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6688979-Animals,
pubmed-meshheading:6688979-Bone Resorption,
pubmed-meshheading:6688979-Bone and Bones,
pubmed-meshheading:6688979-Calcitriol,
pubmed-meshheading:6688979-Calcium, Dietary,
pubmed-meshheading:6688979-Cell Count,
pubmed-meshheading:6688979-Male,
pubmed-meshheading:6688979-Osteoblasts,
pubmed-meshheading:6688979-Osteoclasts,
pubmed-meshheading:6688979-Phosphorus,
pubmed-meshheading:6688979-Prednisolone,
pubmed-meshheading:6688979-Rats,
pubmed-meshheading:6688979-Rats, Inbred Strains
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pubmed:year |
1983
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pubmed:articleTitle |
Studies of bone tissue in rats treated by prednisolone and 1,25-(OH)2D3.
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pubmed:publicationType |
Journal Article,
Comparative Study
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