Linked Life Data

6686560

Source:http://linkedlifedata.com/resource/pubmed/id/6686560

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1984-3-23
pubmed:abstractText
6-oxo-prostaglandin E1 (6-oxo-PGE1), has recently been postulated as being a possible metabolite of PGI2 and/or 6-oxo-PGF1 alpha. This compound possesses a vasodilatory, renin secretion activity and platelet aggregation inhibiting activity in the dog and rat and is more stable than PGI2. But the systemic effects of 6-oxo-PGE1 on man is not known. The present study was designed, therefore, to determine the effects of 6-oxo-PGE1 on blood pressure (BP), the renin-angiotensin-aldosterone system and platelet aggregability in man. 6 healthy male volunteers (mean age: 24.3 +/- 1.2 years) and one patient with Shy-Drager syndrome (a 57 year old female) were studied. 6-oxo-PGE1, dissolved in physiological saline, was infused intravenously at three different doses of 7.5, 15 and 30 ng/kg/min, for 15 min each. Blood samples were collected every 15 minutes for measurements of plasma renin activity (PRA), plasma aldosterone (PA), plasma cortisol (PC) and platelet aggregation inhibiting activity (Agg-inhibition). BP and pulse rate (PR) were recorded every 2 minutes. PRA, PA and PC did not change during or after the infusion. However, the platelet aggregation was significantly (p less than 0.05) inhibited in a dose-dependent manner, and this was still observed at 30 minutes after the termination of the infusion. Neither systolic or diastolic BP changed during the infusion but rose after the termination of the infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0029-0661
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1138-44
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Effects of 6-oxo-PGE1 on the renin-angiotensin-aldosterone system, blood pressure and platelet aggregability in man].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't