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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1983-11-23
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pubmed:abstractText |
Tin-117m-labeled 23-(trimethylstannyl)-24-nor-5 alpha-cholan-3 beta-ol (2) has been prepared by reaction of trimethyl [117mSn]tin lithium with 3 beta-acetoxy-23-bromo-24-nor-5 alpha-cholane (1). Tin-117m (2) shows pronounced adrenal uptake (2.5% injected dose) in female rats 1 day after injection. Furthermore, the adrenal to liver (9.1:1) and adrenal to blood (33.7:1) ratios are high after this period. The absorbed radiation dose values from [117mSn]2 to human organs have also been estimated by using rat tissue distribution and excretion data. [117mSn]2 is the first reported tissue-specific organic radiopharmaceutical labeled with this nuclide and may have potential as an adrenal imaging agent.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1535-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6684691-Adrenal Glands,
pubmed-meshheading:6684691-Animals,
pubmed-meshheading:6684691-Cholanes,
pubmed-meshheading:6684691-Female,
pubmed-meshheading:6684691-Indicators and Reagents,
pubmed-meshheading:6684691-Kidney,
pubmed-meshheading:6684691-Kinetics,
pubmed-meshheading:6684691-Liver,
pubmed-meshheading:6684691-Male,
pubmed-meshheading:6684691-Mass Spectrometry,
pubmed-meshheading:6684691-Ovary,
pubmed-meshheading:6684691-Radioisotopes,
pubmed-meshheading:6684691-Radionuclide Imaging,
pubmed-meshheading:6684691-Rats,
pubmed-meshheading:6684691-Spectrophotometry, Infrared,
pubmed-meshheading:6684691-Tissue Distribution,
pubmed-meshheading:6684691-Trialkyltin Compounds,
pubmed-meshheading:6684691-Trimethyltin Compounds
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pubmed:year |
1983
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pubmed:articleTitle |
Potential tissue-imaging agents: 23-(trimethyl [117mSn]stannyl)-24-nor-5 alpha-cholan-3 beta-ol.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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