Linked Life Data

6684139

Source:http://linkedlifedata.com/resource/pubmed/id/6684139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-10-8
pubmed:abstractText
Immunization of mice with lysates from infected cells and pure vaccinia virus generated hybridomas, a large fraction of which make autoantibodies binding to intermediate filaments (greater than IF) and vimentin. Antibodies that can be detected in preimmune mice as weakly binding to the cytoskeleton (greater than CS) are elevated in potency after immunization with either active or UV-inactivated pure vaccinia, suggesting that virus replication may not be obligatory for activation of greater than CS lymphocyte clones. Demonstration of a cross-reactivity of one IF monoclonal antibody with virally coded hemagglutinin, expressed at the surface, raises questions about the development of pathologic conditions associated with virus-mediated autoimmunity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1546-53
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Infection with vaccinia favors the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them cross-reacting with the virus hemagglutinin.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't