Linked Life Data

6683768

Source:http://linkedlifedata.com/resource/pubmed/id/6683768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-9-20
pubmed:abstractText
The characteristic behavioral effect of methamphetamine (MA) at 2.5 mg/kg was enhanced locomotor activity which lasted over 2.5 hr. At 10.0 mg/kg MA, stereotyped behavior was predominant and lasted over 3 hr. The behavioral effect of 5.0 mg/kg MA was of the mixed type. MA at 5.0 and 10.0 mg/kg lowered the brain NE level from 2 hr after drug treatment, while the accumulation of MHPG-SO4 was increased over 2 hr at 2.5 and 5.0 mg/kg MA. The accumulation of HVA was significantly increased at 10.0 mg/kg MA over 3 hr. Accordingly, the behavioral effects of MA at the earlier period were compatible with the biochemical effects of MA. The behavioral effects during the 2- to 4-hr period, however, seem to be unrelated to the actions on brain catecholamines. Measurement of brain MA concentrations revealed that approx. 2 micrograms/g in the brain may be necessary to produce enhanced locomotor activity and the increased accumulation of brain MHPG-SO4. It appeared that approx. 8 to 9 micrograms/g MA in the brain was required to produce characteristic stereotyped behavior and the increased accumulation of HVA. Therefore, the behavioral and biochemical effects of MA were correlated with the brain MA concentrations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-5198
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-40
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Methamphetamine-induced behavioral effects and releases of brain catecholamines and brain concentrations of methamphetamine in mice.
pubmed:publicationType
Journal Article