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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-6-17
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pubmed:abstractText |
Early replication of prometaphasic human sex chromosomes was studied with the bromodeoxyuridine (BrdU)-replication technique. The studies reveal that two distal segments of Xp, including bands Xp 22.13 and Xp 22.3, replicate early in S-phase and therefore may not be subject to random inactivation. Furthermore, the replication of these distal segments of Xp occurs synchronously with those of the short arm of the Y chromosome including bands Yp 11.2 and Yp 11.32. These segments of Xp and Yp correspond well to the pairing segment of the X and Y chromosomes where a synaptonemal complex forms at early pachytene of human spermatogenesis. The homologous early replication of Yp and the distal portion of Xp may be interpreted as a remnant left untouched by the differentiation of heteromorphic sex chromosomes from originally homomorphic autosomes. A third early replicating segment is situated on the long arm of the X chromosome and corresponds to band Xq 13.1. This segment may be correlated with the X-inactivation center postulated by Therman et al. (1979).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0340-6717
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6682404-Bromodeoxyuridine,
pubmed-meshheading:6682404-DNA Replication,
pubmed-meshheading:6682404-Female,
pubmed-meshheading:6682404-Humans,
pubmed-meshheading:6682404-Karyotyping,
pubmed-meshheading:6682404-Klinefelter Syndrome,
pubmed-meshheading:6682404-Lymphocytes,
pubmed-meshheading:6682404-Male,
pubmed-meshheading:6682404-Sex Chromosomes,
pubmed-meshheading:6682404-X Chromosome,
pubmed-meshheading:6682404-Y Chromosome
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pubmed:year |
1983
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pubmed:articleTitle |
Cytologic evidence for three human X-chromosomal segments escaping inactivation.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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