Linked Life Data

6680999

Source:http://linkedlifedata.com/resource/pubmed/id/6680999

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-4-10
pubmed:abstractText
When male Wistar rats are fed a high fat and cholesterol diet, the small lesions in the caudal artery which form spontaneously with age exhibit, to various degrees, focal accumulation of lipids. Lesions in the proximal part of the artery show more intense lipid deposits than those in the distal part. In order to determine the influence of changes in hemodynamic factors on lipid accumulation within these lesions, a stenosis was experimentally induced in the proximal part of the caudal artery in 15, 5-week old rats. These rats, plus 15 age-matched controls, were then fed a high fat and cholesterol diet for 8 weeks and thereafter their caudal arteries were taken for histological examination and quantification of lipid deposits within lesions. Results showed that in the stenosed arteries, the mean percentage of highly fatty lesions was significantly decreased and that of fat-free lesions was significantly increased distal to the stenosis compared to control arteries, indicating the importance of hemodynamic factors in the deposition of nutritional lipids within spontaneous arterial lesions. However, within the stenosed group, there was apparently no correlation between the degree of stenosis and the extent of fat deposits within lesions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-6127
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
182-98
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Decreased dietary lipid deposition in spontaneous lesions distal to a stenosis in the rat caudal artery.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't