Linked Life Data

6679642

Source:http://linkedlifedata.com/resource/pubmed/id/6679642

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-11-21
pubmed:abstractText
Alphadione, a steroidal anesthetic formulation containing alphaxalone (3 alpha-hydroxy-5 alpha-pregnane-11, 20-dione) and alphadolone acetate (21-acetoxy-3 alpha-hydoroxy-5 alpha-pregnane-11, 20-dione) in polyoxyethylated castor oil (Cremophor EL) owes its short duration of action to rapid metabolic transformation rather than the redistribution into the body fat. Treatment of rats with alphadione (1 ml/kg; intraperitoneal route) induced an increase in the cytochrome P-450 content of the liver. The difference spectra were obtained only when alphadione or alphaxalone was added to the liver microsomal suspension while neither alphadolone acetate nor Cremophor EL induced any spectral changes. The spectral dissociation constant (Ks) for alphaxalone was 2.5 X 10(-3) mM suggesting that hydroxylation of alphaxalone is a cytochrome P-450 dependent reaction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0387-821X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Spectral studies on the effect of a new steroidal anesthetic agent alphadione on rat hepatic microsomes.
pubmed:publicationType
Journal Article