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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1984-11-1
|
| pubmed:abstractText |
The hydrolysis rate of 9-chloro-11 beta, 17a-dihydroxy-16 beta-methyl-21-(1'4'N-acetyltransaminomethyl- cyclohexancarbonyloxy) pregna-1,4-diene-3,20-dione (cyclomethasone) and of beclomethasone 17,21-dipropionate was studied on human lung slices. Cyclomethasone is hydrolysed more slowly than beclomethasone 17,21-dipropionate. This difference may be ascribed to a different affinity and/or activity of the tissue esterases towards the two substrates or to a different transport rate in the sites of the esterase activity. Since the steroid moiety is the same for both molecules studied it appears that the hydrolysis and/or the transport rate of the esterified steroids depends on the chemical properties of the substituent at C-21.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0251-1649
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
17-20
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1983
|
| pubmed:articleTitle |
Hydrolysis of cyclomethasone by the human lung.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|