Linked Life Data

6676108

Source:http://linkedlifedata.com/resource/pubmed/id/6676108

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1984-7-9
pubmed:abstractText
Extracellular recordings were made from neurones in the zona compacta of the substantia nigra in a novel slice preparation in vitro. The pharmacological profile of some dopamine related drugs was assessed by their depressant action on neuronal firing after known concentrations were added to the perfusing media. The most potent drugs were the rigid stable dopamine analogues 2-amino-6,7-dihydroxy-1,2,3,4- tetrahydronapthalene (ADTN) and apomorphine. 2-Amino-5,6-dihydroxy-1,2,3,4- tetrahydronapthalene (5,6-ATN), was less potent than either. Octopamine, Norphenephrine , m- and p-tyramine were all less potent than dopamine. Although noradrenaline was equipotent to dopamine, alpha- and beta-adrenoreceptors were not involved since propranolol and phentolamine were not antagonists, while (-)-sulpiride, haloperidol and alpha-flupentixol were potent antagonists of the dopamine mediated responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-76
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Sensitivity of compacta neurones in the rat substantia nigra slice to dopamine agonists.
pubmed:publicationType
Journal Article, In Vitro