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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1978-9-15
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pubmed:abstractText |
1 Electrically evoked and resting overflow of tritium was measured from mouse vas deferens previously incubated with [3H]-(--)-noradrenaline. 2 At low concentrations (1.6 X 10(-7) to 4 X 10(-6)M) amitriptyline increased only the evoked tritium overfow while higher concentrations increased both evoked and resting overflow. 3 In the presence of atropine (1 X 10(-6 M) amitriptyline still produced an increase in evoked tritium overflow. 4 In the presence of a concentration of cocaine (1.1 X 10(-5) M) which produced a maximal blockade of the uptake of exogenous noradrenaline the application of amitriptyline still produced an increase in evoked tritium overflow. 5 In the presence of a concentration of phentolamine (1 X 10(-5) M) that produced complete blockade of the presynaptic alpha-adrenoceptors, amitriptyline still produced an increase in evoked tritium overflow. 6 In the presence of cocaine and phentolamine together the effect of amitriptyline on evoked overflow was abolished. 7 It is concluded that amitriptyline may raise synaptic levels of noradrenaline by blocking presynaptic alpha-adrenoceptors controlling noradrenaline release and by blocking its uptake into sympathetic neurones.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-1161046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-136668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-13873299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-14050417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-14389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-20190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-410061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-4156564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-4335682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-4754681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-5060401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-5125333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-5345888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-5701155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-5786092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-6040438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/667423-870126
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:667423-Amitriptyline,
pubmed-meshheading:667423-Animals,
pubmed-meshheading:667423-Atropine,
pubmed-meshheading:667423-Cocaine,
pubmed-meshheading:667423-Electric Stimulation,
pubmed-meshheading:667423-Male,
pubmed-meshheading:667423-Mice,
pubmed-meshheading:667423-Nervous System,
pubmed-meshheading:667423-Norepinephrine,
pubmed-meshheading:667423-Phentolamine,
pubmed-meshheading:667423-Vas Deferens
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pubmed:year |
1978
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pubmed:articleTitle |
The effect of amitriptyline on presynaptic mechanisms in noradrenergic nerves.
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pubmed:publicationType |
Journal Article,
In Vitro
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