Linked Life Data

6673372

Source:http://linkedlifedata.com/resource/pubmed/id/6673372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1984-5-21
pubmed:abstractText
Within 8 h after i.v. administration of paracetamol (100 mg/kg) to rats, 28.7% was excreted into bile; 1.2% dose as unchanged drug, 14.3% as the glucuronide, 8.2% as the sulphate, 4.7% as the glutathione conjugate, 0.32% as the mercapturate. Rats with cannulated bile-ducts excreted 62.8% dose in the urine in 8 h compared with 83.5% in sham-operated rats. Metabolites in urine were paracetamol sulphate (63.2%), the glucuronide (12.1%), unchanged paracetamol (7%), and the mercapturate (1.2%). Bile containing paracetamol and its conjugates was infused into the duodenum and within 8 h 45.3% was excreted (5.6% in bile and 39.7% in urine). In rats not subjected to surgery, 91.3% dose (100 mg/kg, i.v.) was excreted in urine in 24 h. However, in rats treated twice with activated charcoal or cholestyramine (2 X 1 g/kg orally), urine excretion was decreased to 72.8 and 59.3% dose, respectively. These results indicate the enterohepatic circulation of paracetamol and its metabolites in the rat.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
591-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Biliary excretion and enterohepatic circulation of paracetamol in the rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't