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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1984-5-24
|
| pubmed:abstractText |
A rapid and sensitive method for the determination of cyclophosphamide (CP) and 5-fluorouracil (5-FU) and some of their metabolites in one analysis has been developed. Surface-coated open-tubular OV-275 columns were combined with electron-capture detection and nitrogen-phosphorus selective detection. The influence of the column diameter on the separation is shown. Extraction with 2-propanol-diethyl ether (22:77) allows the isolation of CP, 5-FU and their analogues in one extraction step. The assay was applied to some pharmacokinetic experiments with chemotherapeutically treated patients and with a WAG/Rij rat.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0021-9673
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
279
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
603-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6672038-Animals,
pubmed-meshheading:6672038-Chromatography, Gas,
pubmed-meshheading:6672038-Cyclophosphamide,
pubmed-meshheading:6672038-Electrons,
pubmed-meshheading:6672038-Fluorouracil,
pubmed-meshheading:6672038-Humans,
pubmed-meshheading:6672038-Nitrogen,
pubmed-meshheading:6672038-Phosphorus,
pubmed-meshheading:6672038-Rats,
pubmed-meshheading:6672038-Temperature
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Determination of the underivatized antineoplastic drugs cyclophosphamide and 5-fluorouracil and some of their metabolites by capillary gas chromatography combined with electron-capture and nitrogen-phosphorus selective detection.
|
| pubmed:publicationType |
Journal Article
|