Linked Life Data

6667682

Source:http://linkedlifedata.com/resource/pubmed/id/6667682

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-3-28
pubmed:abstractText
In a study of the immunomodulating properties of metronidazole and its two main metabolites, metronidazole and 1-(2-hydroxyethyl-2-hydroxymethyl)-5-nitro-imidazole (hydroxy metabolite) were seen to enhance the phytohaemagglutinin-A-stimulated mitogenic transformation of murine lymphocytes. The stimulation was observed at suboptimal phytohaemagglutinin concentrations. The lymphocyte transformation was suppressed by 1-acetic acid-2-methyl-5-metronidazole (acid metabolite). The enhancement by metronidazole and its hydroxy metabolite was observed at concentrations corresponding to human serum levels following a normal dosage of metronidazole. Considering the normal serum concentrations of the three substances, the stimulating effect of the hydroxy metabolite may be at least as important as that of metronidazole itself.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0722-2211
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
568-70
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The influence of metronidazole and its two main metabolites on murine in vitro lymphocyte transformation.
pubmed:publicationType
Journal Article