Linked Life Data

6665311

Source:http://linkedlifedata.com/resource/pubmed/id/6665311

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-3-19
pubmed:abstractText
The pharmacokinetics and metabolism of intramuscularly administered ketamine (25 mg/kg) were determined in eight cats (group A). The effect of prior administration of the sedative agent xylazine hydrochloride (1 mg/kg intramuscularly) on the uptake distribution and metabolism of the drug was also investigated in another 10 cats (group B). It was found that xylazine significantly prolonged the duration of ketamine anaesthesia. In addition, xylazine not only prolonged the plasma half life of ketamine but significantly delayed the production of the primary metabolite of ketamine, norketamine. Studies on the urinary excretion of ketamine and norketamine in the cats in group B indicated that very little of the drug (less than 2.6 per cent) is excreted by this route in the initial 90 minutes after injection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0034-5288
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-90
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Influence of premedication with xylazine on the distribution and metabolism of intramuscularly administered ketamine in cats.
pubmed:publicationType
Journal Article