Linked Life Data

6664236

Source:http://linkedlifedata.com/resource/pubmed/id/6664236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-3-2
pubmed:abstractText
Recording were made for dorsal horn convergent neurones with hindpaw receptive fields. Response to C-fibre activation was conditioned by noxious heat (52 degrees C) applied to the tail, this resulting in profound inhibition (Diffuse Noxious Inhibitory Controls - DNIC). The microinjection of 5 micrograms morphine into the medioventral PAG, including the n. raphé dorsalis, consistently reduced DNIC without affecting the unconditioned C-fibre responses; more lateral injections had no clear effects. Including a further study in which 20 micrograms morphine was microinjected within various PAG sites, C-fibre responses were found to be unaltered (21/51) enhanced (16/51) or reduced (4/51) with no consistent anatomical basis. The results imply that supraspinal morphine can reduce descending inhibitions and this may contribute to the consequent analgesia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
33 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
549-52
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Morphine microinjections into periaqueductal grey matter of the rat: effects on dorsal horn neuronal responses to C-fibre activity and diffuse noxious inhibitory controls.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't