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rdf:type |
|
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lifeskim:mentions |
|
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pubmed:issue |
12
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pubmed:dateCreated |
1984-3-1
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|
pubmed:abstractText |
To evaluate the reproductive consequences of prenatal diethylstilbestrol (DES) exposure, 33 infertile couples were studied in whom the female had been exposed to DES in utero. Infertility was attributed to uterotubal junction obstruction in 3 couples, anovulation in 7, endometriosis in 11, cervical obstruction in 2, adnexal adhesions in 2, oligospermia in 1 and luteal insufficiency in 3; in 4 couples no cause of infertility could be identified. No unique intraabdominal abnormalities attributable to DES exposure were observed. Four tubal pregnancies occurred in women with grossly normal oviducts. Nine of 11 women who had previously undergone surgical manipulation of the cervix (cryosurgery, cautery or conization) developed cervical stenosis, and 8 of them were found to have endometriosis. Despite our not having an appropriate referral infertility population for comparison, these findings are consistent with the following hypotheses regarding women prenatally exposed to DES: (1) surgical manipulation of the cervix more frequently leads to cervical stenosis and ultimately pelvic endometriosis, (2) tubal pregnancies may occur by a mechanism unrelated to salpingitis, and (3) the spectrum of problems causing infertility is similar to that in the non-DES-exposed population.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/ADHESIONS,
http://linkedlifedata.com/resource/pubmed/keyword/Anovulation,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Estrogen,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female,
http://linkedlifedata.com/resource/pubmed/keyword/Data Collection,
http://linkedlifedata.com/resource/pubmed/keyword/Diethylstilbestrol--complications,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Endometrial Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Endometrium,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, Female,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Infertility--etiology,
http://linkedlifedata.com/resource/pubmed/keyword/Information,
http://linkedlifedata.com/resource/pubmed/keyword/Information Processing,
http://linkedlifedata.com/resource/pubmed/keyword/Menstruation,
http://linkedlifedata.com/resource/pubmed/keyword/Menstruation Disorders,
http://linkedlifedata.com/resource/pubmed/keyword/Ovarian Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Ovary,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/RECORDS,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Control Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Signs And Symptoms,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital System,
http://linkedlifedata.com/resource/pubmed/keyword/Uterine Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Uterus,
http://linkedlifedata.com/resource/pubmed/keyword/Vagina
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
|
pubmed:issn |
0024-7758
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
851-6
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pubmed:dateRevised |
2004-11-17
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|
pubmed:otherAbstract |
PIP: To evaluate the reproductive consequences of prenatal diethylstilbestrol (DES) exposure, 33 infertile couples were studied in whom the female had been exposed to DES in utero. Infertility was attributed to uterotubal junction obstruction in 3 couples, anovulation in 7, endometriosis in 11, cervical obstruction in 2, adnexal adhesions in 2, oligospermia in 1, and luteal insufficiency in 3; in 4 couples no cause of infertility could be identified. No unique intraabdominal abnormalities attributable to DES exposure were observed. 4 tubal pregnancies occurred in women with grossly normal oviducts. 9 of 11 women who had previously undergone surgical manipulation of the cervix (cryosurgery, cautery, or conization) developed cervical stenosis, and 8 were found to have endometriosis. Despite our not having an appropriate referral infertility population for comparison, these findings are consistent with these hypotheses regarding women prenatally exposed to DES: 1) surgical manipulation of the cervix more frequently leads to cervical stenosis and ultimately pelvic endometriosis; 2) tubal pregnancies may occur by a mechanism unrelated to salpingitis; and 3) the spectrum of problems causing infertility is similar to that in the non-DES-exposed population.
|
|
pubmed:meshHeading |
pubmed-meshheading:6663585-Adult,
pubmed-meshheading:6663585-Anovulation,
pubmed-meshheading:6663585-Diethylstilbestrol,
pubmed-meshheading:6663585-Endometriosis,
pubmed-meshheading:6663585-Fallopian Tube Diseases,
pubmed-meshheading:6663585-Female,
pubmed-meshheading:6663585-Humans,
pubmed-meshheading:6663585-Hysterosalpingography,
pubmed-meshheading:6663585-Infertility, Female,
pubmed-meshheading:6663585-Pregnancy,
pubmed-meshheading:6663585-Pregnancy, Ectopic,
pubmed-meshheading:6663585-Prenatal Exposure Delayed Effects,
pubmed-meshheading:6663585-Uterine Neoplasms
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|
pubmed:year |
1983
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|
pubmed:articleTitle |
Infertility in women exposed to diethylstilbestrol in utero.
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pubmed:publicationType |
Journal Article
|
