|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1984-3-23
|
|
pubmed:abstractText |
We have observed two cases of chlorpromazine-induced neuroleptic malignant syndrome (NMS); both were transiently responsive to intravenous diazepam challenge, but not to blind placebo or amyobarbitol. The interrelationship, via feedback between central dopaminergic and gamma-aminobutyric (GABA) systems is reviewed. A theoretical role for a relative DA-GABA imbalance during NMS and treatment implications are discussed.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0006-3223
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1441-6
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6661471-Brain,
pubmed-meshheading:6661471-Chlorpromazine,
pubmed-meshheading:6661471-Diazepam,
pubmed-meshheading:6661471-Dopamine,
pubmed-meshheading:6661471-Dyskinesia, Drug-Induced,
pubmed-meshheading:6661471-Dystonia,
pubmed-meshheading:6661471-Female,
pubmed-meshheading:6661471-Fever,
pubmed-meshheading:6661471-Humans,
pubmed-meshheading:6661471-Male,
pubmed-meshheading:6661471-Middle Aged,
pubmed-meshheading:6661471-Syndrome,
pubmed-meshheading:6661471-gamma-Aminobutyric Acid
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Chlorpromazine-induced neuroleptic malignant syndrome and its response to diazepam.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|
