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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1984-2-14
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pubmed:abstractText |
The in vitro transport of 125I-albumin across the endothelial-injured canine aortic preparation was studied as a function of pressure (P) at various locations (z) along the vessel from stirred and quiescent reagents [serum (S) and a comparable albumin (A) reagent] to study mechanisms of vascular protein accumulation. Uptake (M, nmol X cm-2) was calculated from tissue radioactivity and strain-corrected vessel specimen surface area. Corresponding transmural concentration distributions [c(x)] were measured by quantitative microautoradiography. The results showed that 1) M and c(x) increased with P, decreased with z, and were lower from S than from A; 2) changes in M with stirring failed to demonstrate significant concentration gradients in the liquid at the vessel interface even with large uptake rates; 3) the c(x) contours were consistent with simple diffusion and convection in a homogeneous slab; 4) c(x) in the media near the intima increased with P above the assumed equilibrium concentration, suggesting interstitial solute rejection or edema formation with P; and 5) lower c(x) with S than A was consistent with a decreased reagent albumin activity, tissue binding, or tissue hydration.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
245
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
H977-91
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6660318-Animals,
pubmed-meshheading:6660318-Aorta, Thoracic,
pubmed-meshheading:6660318-Dogs,
pubmed-meshheading:6660318-Endothelium,
pubmed-meshheading:6660318-Iodine Radioisotopes,
pubmed-meshheading:6660318-Kinetics,
pubmed-meshheading:6660318-Mathematics,
pubmed-meshheading:6660318-Methods,
pubmed-meshheading:6660318-Models, Biological,
pubmed-meshheading:6660318-Pressure,
pubmed-meshheading:6660318-Regression Analysis,
pubmed-meshheading:6660318-Serum Albumin
|
pubmed:year |
1983
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pubmed:articleTitle |
Effect of pressure and stirring on in vitro aortic transmural 125I-albumin transport.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|