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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1984-2-24
|
| pubmed:abstractText |
Among 22 cases of drug-induced acute interstitial nephritis (AIN), noncaseating interstitial granulomas were found in eight cases (36%). Acute renal failure (ARF), oliguric in three patients, appeared within 1-20 days after the beginning of therapy. Clinical symptoms suggesting a hypersensitivity reaction were unusual, marked blood eosinophilia was absent, and immunologic tests were inconstantly positive. The discovery of interstitial granulomas may be a clue to the diagnosis of drug-induced AIN, especially when the inflammatory infiltrates do not contain eosinophils. Since significant residual renal impairment may be observed the benefit of early steroid therapy must be debated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0071-2736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
646-9
|
| pubmed:dateRevised |
2008-2-21
|
| pubmed:meshHeading |
pubmed-meshheading:6657685-Adolescent,
pubmed-meshheading:6657685-Adult,
pubmed-meshheading:6657685-Aged,
pubmed-meshheading:6657685-Female,
pubmed-meshheading:6657685-Granuloma,
pubmed-meshheading:6657685-Humans,
pubmed-meshheading:6657685-Male,
pubmed-meshheading:6657685-Middle Aged,
pubmed-meshheading:6657685-Nephritis, Interstitial
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Drug-induced granulomatous interstitial nephritis.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|