Linked Life Data

6653663

Source:http://linkedlifedata.com/resource/pubmed/id/6653663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1984-2-14
pubmed:abstractText
Acute administration of 3-3-hydroxyphenyl-N-n-propyl-piperidine (3-PPP), selectively increased intracellular serotonin (5-HT) fluorescence in the dorsal raphe and 5-HT as well as 5-hydroxyindoleacetic acid (5-HIAA) in the corresponding projection site of the dorsal raphe, the striatum. These effects are similar to those produced by systemic treatments with apomorphine (APO). Serotonin neurons in the median raphe and its corresponding terminal area hippocampus were not affected by either APO or 3-PPP. Haloperidol at a dose having no significant effect alone, antagonized the APO-induced elevation of striatal 5-HT. The differential effects of 3-PPP on the mesostriatal and mesolimbic serotonergic systems further confirm that the dorsal and median raphe nuclei constitute two anatomically and functionally distinct cell groups and the similarities of the effects of APO and 3-PPP indicate that dopamine autoreceptors may mediate the observed effects of APO on 5-HT neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
297-303
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Similarities of the effects of apomorphine and 3-PPP on serotonin neurons.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't