| pubmed-article:6652358 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6652358 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:6652358 | lifeskim:mentions | umls-concept:C0020885 | lld:lifeskim |
| pubmed-article:6652358 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:6652358 | lifeskim:mentions | umls-concept:C0062961 | lld:lifeskim |
| pubmed-article:6652358 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6652358 | pubmed:dateCreated | 1984-2-14 | lld:pubmed |
| pubmed-article:6652358 | pubmed:abstractText | Homotaurine (3-aminopropane sulphonic acid) did not inhibit the twitch response in guinea-pig ileum longitudinal muscle whilst gamma-aminobutyric acid (GABA) and (-)-baclofen evoked dose-dependent inhibitions. The inhibitory effects of GABA and (-)-baclofen were prevented in the presence of homotaurine 2 X 10(-4) and 10(-3) M. The log dose-effect curves of GABA and (-)-baclofen were shifted in a parallel manner compatible with competitive antagonism. The pA2 of homotaurine with GABA (4.22 +/- 0.05) and (-)-baclofen (4.26 +/- 0.1) were the same. Homotaurine did not antagonize the inhibitory effects of morphine (ED50 4 X 10(-7) M), noradrenaline (ED50 10(-6) M) or ATP (ED50 1.5 X 10(-5) M). The inferior homologue of homotaurine, taurine 10(-3) M, did not modify the inhibitory effects of GABA and (-)-baclofen. Picrotoxin 5 X 10(-5) M antagonized GABAA receptor-mediated contraction but did not affect GABAB receptor-mediated inhibition. At the same concentration the drug did not influence the antagonistic action of homotaurine, thus showing no GABAA receptor-mediated interference. It may be concluded that homotaurine is a competitive antagonist of GABAB mediated effects in the guinea-pig ileum. | lld:pubmed |
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| pubmed-article:6652358 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6652358 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6652358 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6652358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6652358 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6652358 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6652358 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:6652358 | pubmed:author | pubmed-author:GiottiAA | lld:pubmed |
| pubmed-article:6652358 | pubmed:author | pubmed-author:ZillettiLL | lld:pubmed |
| pubmed-article:6652358 | pubmed:author | pubmed-author:LuzziSS | lld:pubmed |
| pubmed-article:6652358 | pubmed:author | pubmed-author:SpagnesiSS | lld:pubmed |
| pubmed-article:6652358 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6652358 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:6652358 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6652358 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6652358 | pubmed:pagination | 855-62 | lld:pubmed |
| pubmed-article:6652358 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6652358 | pubmed:meshHeading | pubmed-meshheading:6652358-... | lld:pubmed |
| pubmed-article:6652358 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6652358 | pubmed:articleTitle | Homotaurine: a GABAB antagonist in guinea-pig ileum. | lld:pubmed |
| pubmed-article:6652358 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6652358 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:6652358 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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