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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1984-2-14
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pubmed:abstractText |
Homotaurine (3-aminopropane sulphonic acid) did not inhibit the twitch response in guinea-pig ileum longitudinal muscle whilst gamma-aminobutyric acid (GABA) and (-)-baclofen evoked dose-dependent inhibitions. The inhibitory effects of GABA and (-)-baclofen were prevented in the presence of homotaurine 2 X 10(-4) and 10(-3) M. The log dose-effect curves of GABA and (-)-baclofen were shifted in a parallel manner compatible with competitive antagonism. The pA2 of homotaurine with GABA (4.22 +/- 0.05) and (-)-baclofen (4.26 +/- 0.1) were the same. Homotaurine did not antagonize the inhibitory effects of morphine (ED50 4 X 10(-7) M), noradrenaline (ED50 10(-6) M) or ATP (ED50 1.5 X 10(-5) M). The inferior homologue of homotaurine, taurine 10(-3) M, did not modify the inhibitory effects of GABA and (-)-baclofen. Picrotoxin 5 X 10(-5) M antagonized GABAA receptor-mediated contraction but did not affect GABAB receptor-mediated inhibition. At the same concentration the drug did not influence the antagonistic action of homotaurine, thus showing no GABAA receptor-mediated interference. It may be concluded that homotaurine is a competitive antagonist of GABAB mediated effects in the guinea-pig ileum.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-13996119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-14099720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-16993814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-241459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-4151806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-4154116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-4295753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-4302725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-4398801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-4754853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-551269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-6263651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-6289954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-6301600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-7084308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652358-732891
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
855-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6652358-Animals,
pubmed-meshheading:6652358-Baclofen,
pubmed-meshheading:6652358-Electric Stimulation,
pubmed-meshheading:6652358-GABA Antagonists,
pubmed-meshheading:6652358-Guinea Pigs,
pubmed-meshheading:6652358-Ileum,
pubmed-meshheading:6652358-Male,
pubmed-meshheading:6652358-Muscle, Smooth,
pubmed-meshheading:6652358-Muscle Contraction,
pubmed-meshheading:6652358-Picrotoxin,
pubmed-meshheading:6652358-Taurine
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pubmed:year |
1983
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pubmed:articleTitle |
Homotaurine: a GABAB antagonist in guinea-pig ileum.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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