Linked Life Data

6650178

Source:http://linkedlifedata.com/resource/pubmed/id/6650178

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-1-7
pubmed:abstractText
Isolated hamster lungs were ventilated with smoke from low-, medium-and high-tar cigarettes when 45 nmol of 14C-arachidonic acid was infused into the pulmonary circulation. Most of the infused radioactivity was found in different phospholipid and neutral lipid fractions of the perfused lungs and a smaller amount was found in the nonrecirculating perfusion effluent mainly as metabolites. Cigarette smoke ventilation increased the amount of 14C-arachidonic acid in the triacylglycerols of the perfused lungs but had usually no effect on the amount of radioactivity in diacylglycerols or in different phospholipids. The increased amount of radiolabel in triacylglycerols was significantly greater in the lungs ventilated with smoke from medium-or high-tar cigarettes than in those ventilated with low-tar cigarette smoke. Cigarette smoke ventilation increased the amount of unmetabolized arachidonate in the perfusion effluent and decreased the amount of many metabolites. The present study indicates that low-, medium- and high-tar cigarettes have effects of the fate and metabolism of arachidonic acid in isolated hamster lungs and that the effects of medium- and high-tar cigarettes are more clear that those of low-tar cigarettes when the cigarettes are burned with a constant puff volume and rate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0001-6683
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
280-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The effect of low-, medium- and high-tar cigarette smoke on the fate of arachidonic acid in isolated hamster lungs.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't