Linked Life Data

6648525

Source:http://linkedlifedata.com/resource/pubmed/id/6648525

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4628
pubmed:dateCreated
1984-1-7
pubmed:abstractText
Antisera to human syncytiotrophoblast microvillous cell surface membranes from different placentas are cytotoxic for lymphocytes from some people but not others, demonstrating the presence of allotypic trophoblast-lymphocyte cross-reactive (TLX) antigens. Exploratory principal components factor analysis, performed on limited data consisting of 300 cytotoxic reactions produced by ten separate trophoblast antisera on a panel of lymphocytes from 30 random donors, suggested the presence of three distinct TLX antigen groupings. It is proposed that such TLX alloantigens are central in establishing maternal recognition and protection of the blastocyst, and that lack of recognition results in implantation failure and spontaneous abortion. These findings are compatible with contemporary results of immunotherapy to prevent recurrent spontaneous abortions, and their implications extend to other conditions of allogeneic coexistence, such as organ transplantation and the tumor-host relationship.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
222
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1135-7
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Human trophoblast-lymphocyte cross-reactive (TLX) antigens define a new alloantigen system.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't