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pubmed-article:6646234pubmed:abstractTextNucleotide sequence and deletion analysis have been used to identify the regulatory and coding sequences comprising the cholera toxin operon (ctx). Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development.lld:pubmed
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pubmed-article:6646234pubmed:articleTitleCholera toxin genes: nucleotide sequence, deletion analysis and vaccine development.lld:pubmed
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