Linked Life Data

6644533

Source:http://linkedlifedata.com/resource/pubmed/id/6644533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1984-1-7
pubmed:abstractText
The purpose of this investigation is to correlate between trimethadione (TMO) metabolism and hepatic microsomal drug-oxidizing activities in different animal species (mouse, hamster, rat and rabbit). A good correlation was obtained between the plasma concentration ratio of 5,5-dimethyl-2,4-oxazolidinedione (DMO) to TMO and relative activities of aminopyrine (r = 0.999 at 1 h, p less than 0.01; r = 0.994 at 2 h, p less then 0.01) and TMO (r = 0.988 at 1 h, p less than 0.02; r = 0.975 at 2 h, p less than 0.05) N-demethylase, and aniline (r = 0.993 at 1 h, p less than 0.01; r = 0.979 at 2 h, p less than 0.01) hydroxylase. These results indicate that the values of plasma DMO/TMO ratio determined at an appropriate time period following its administration would be reflecting the degree of hepatic drug-oxidizing capacity in various experimental animal species. These findings thus suggest that in vivo TMO metabolism would be a useful drug for predicting hepatic drug-oxidizing capacity in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0386-846X
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
481-6
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Relationship between trimethadione metabolism and hepatic drug-oxidizing enzyme activities in different animal species.
pubmed:publicationType
Journal Article