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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1984-1-27
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pubmed:abstractText |
Fibroblasts from hamster embryos were serially cultivated in vitro and their evolution followed from a morphological, physiological and biochemical point of view. After an exponential growth for about 20 passages, cells entered the ageing phase which ended up after 29-34 passages. From our observations, it seems that the arrest of growth results from two different phenomena: first, the typically fibroblastic cells may undergo a stochastic ageing process; second, some of these cells evolve into a terminal differentiation process, characterized by a different non-fibroblastic phenotype.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0531-5565
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
223-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6641824-Aging,
pubmed-meshheading:6641824-Animals,
pubmed-meshheading:6641824-Cell Differentiation,
pubmed-meshheading:6641824-Cell Division,
pubmed-meshheading:6641824-Cell Survival,
pubmed-meshheading:6641824-Cells, Cultured,
pubmed-meshheading:6641824-Cricetinae,
pubmed-meshheading:6641824-Glucosephosphate Dehydrogenase,
pubmed-meshheading:6641824-Hot Temperature,
pubmed-meshheading:6641824-Microscopy, Electron,
pubmed-meshheading:6641824-Stochastic Processes
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pubmed:year |
1983
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pubmed:articleTitle |
Ageing of hamster embryo fibroblasts as the result of both differentiation and stochastic mechanisms.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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