rdf:type |
|
lifeskim:mentions |
umls-concept:C0002395,
umls-concept:C0006104,
umls-concept:C0010097,
umls-concept:C0011268,
umls-concept:C0016296,
umls-concept:C0030705,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0039485,
umls-concept:C0162512,
umls-concept:C1167622
|
pubmed:issue |
1-2
|
pubmed:dateCreated |
1984-1-27
|
pubmed:abstractText |
In agreement with other workers we report increased [3H]R05-4864 binding in kainate-lesioned rat striatum. [3H]R05-4864 binding, a possible glial marker, was also increased in temporal cortex obtained post-mortem from patients with Alzheimer's disease. [3H]Flunitrazepam binding was decreased in these brain samples, possibly indicative of neuronal cell loss. It is suggested that the poor binding characteristics of [3H]R05-4864 in human brain samples may limit its usefulness in assessing gliosis.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0006-8993
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
14
|
pubmed:volume |
278
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
373-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6640329-Aged,
pubmed-meshheading:6640329-Alzheimer Disease,
pubmed-meshheading:6640329-Animals,
pubmed-meshheading:6640329-Benzodiazepinones,
pubmed-meshheading:6640329-Binding Sites,
pubmed-meshheading:6640329-Corpus Striatum,
pubmed-meshheading:6640329-Female,
pubmed-meshheading:6640329-Flunitrazepam,
pubmed-meshheading:6640329-Glutamate Decarboxylase,
pubmed-meshheading:6640329-Humans,
pubmed-meshheading:6640329-Kainic Acid,
pubmed-meshheading:6640329-Male,
pubmed-meshheading:6640329-Pyrrolidines,
pubmed-meshheading:6640329-Rats,
pubmed-meshheading:6640329-Temporal Lobe,
pubmed-meshheading:6640329-Tritium
|
pubmed:year |
1983
|
pubmed:articleTitle |
[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|