Linked Life Data

6640206

Source:http://linkedlifedata.com/resource/pubmed/id/6640206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-1-27
pubmed:abstractText
Tissue bath experiments showed that potassium chloride (KC1) at 10-40 mmoll-1 evoked spasm of guinea-pig trachealis which was unaffected by atropine (1 mumoll-1), mepyramine (1 mumoll-1), tetrodotoxin (3 mumoll-1) or indomethacin (2.8 mumoll-1). Spasm evoked by KC1 was depressed in Ca2+-free Krebs solution or by exposure of tissues to LaCl3 (0.25-1 mmoll-1). Extracellular electrical recording showed that the spasm evoked by KCl 10 mmoll-1 was associated with promotion of electrical slow wave activity. Higher concentrations of KC1 abolished slow wave activity but caused further tension development. Intracellular recording confirmed the ability of KC1 10 mmoll-1 transiently to promote slow wave activity in individual trachealis cells. This action was associated with depolarization and tension development. Higher concentrations of KC1 evoked further tension development but slow waves were suppressed as the depolarization evoked by KC1 increased. KC1 (10-40 mmoll-1) increased the lanthanum-resistant calcium fraction of muscle-containing strips of trachea. It is concluded that KC1 acts directly on the smooth muscle of guinea-pig trachea. The spasmogenic action is associated with transient promotion of slow wave activity and a fall in resting membrane potential. The spasm involves the cellular influx of Ca2+ and is dependent on the presence of Ca2+ in the extracellular fluid.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-1003694, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-1119583, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-1142117, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-1236606, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-37533, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-6788415, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-6871547, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-6871556, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-7126995, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-7357211, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-7394375, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-850140, http://linkedlifedata.com/resource/pubmed/commentcorrection/6640206-859102
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
553-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The spasmogenic action of potassium chloride in guinea-pig trachealis.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't