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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-12-20
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pubmed:abstractText |
The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 microM) or oxypurinol (100 microM). Since allopurinol at this level clinically has been demonstrated to interfere with 5-fluorouracil anabolism, thereby reducing toxicity owing to 5-fluorouracil, allopurinol may be useful in counteracting the 5-fluorouracil-induced myelotoxicity observed in patients being treated with 5-fluorocytosine without interfering with the antifungal activity of 5-fluorocytosine.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-1098864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-320931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-465283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-5955812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-639435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-6457698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-7236867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-7371020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-742878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-773604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6639003-848928
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
448-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
5-fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol: potential for improving the therapeutic index of 5-fluorocytosine.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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