Linked Life Data

6638533

Source:http://linkedlifedata.com/resource/pubmed/id/6638533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-12-20
pubmed:abstractText
The ultrastructural events in the establishment of the neuromuscular junction of the freely grafted extensor digitorum longus (EDL) muscle of the rat were studied 1-120 days after grafting. The original axons and muscle fibers, including soleplates, degenerated during the first few days, but Schwann cells and basal laminae persisted. Myofibers regenerated within the original basal laminae. Indentations of the sarcolemma, termed "presumptive synaptic clefts" (PSC), were found on myotubes from 7-day grafts. Schwann cells and residual acetylcholinesterase were invariably associated with the PSC, suggesting that the PSC developed at the site of the original soleplate. Nerves entered the grafts 10 days postoperatively and contacted the PSC of the regenerating muscle fibers on the 18-20th day. The secondary synaptic clefts of these "reconstructed" soleplates extended far beyond the subaxonal region. A second type of soleplate appeared on the 18-20th day. These soleplates were similar to those found in embryonic muscle and were considered to have been induced to form "de novo" by the presence of the nerves. When grafts were placed in permanently denervated limbs the "reconstructed" soleplates appeared, but the "de novo" type did not. These results show that information directing the morphogenesis and innervation of the soleplate persists after the original muscle fibers and axons of a graft degenerate and regenerate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-276X
pubmed:author
pubmed:issnType
Print
pubmed:volume
207
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-67
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Development and innervation of soleplates in the freely grafted extensor digitorum longus (EDL) muscle in the rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't