Linked Life Data

6637335

Source:http://linkedlifedata.com/resource/pubmed/id/6637335

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-12-17
pubmed:abstractText
Rats receiving large doses of thyroxine (30 micrograms/5 doses) during their first days of life develop an apparently permanent alteration of the hypothalamus-pituitary-thyroid complex. This neonatal thyrotoxicosis has been called neo-T4 syndrome. A state of permanent but not very severe hypothyroidism seems to be induced, accompanied by a decrease in pituitary GH content at least until day 22. In this work, growth hormone content has been measured by a specific radioimmunoassay in the anterior pituitary of 45 and 78 day old neo-T4 and control (saline-injected) rats. GH content of the adult neo-T4 treated animals was significantly lower than that of the adult controls. Administration of different doses of T4 (1.7 micrograms/100 g body weight/3 doses or 2.5 micrograms/100 g body weight/8 doses, to 70 day old rats, and 5 micrograms/100 g body weight/3 doses to 42 day old rats) to adult neo-T4 rats did not alter these decreased pituitary GH levels. This differs from hypothyroid rats, in which T4 administration has been shown to increase pituitary GH content. A third approach was to thyroidectomize neo-T4 and control rats and administer 5 micrograms T4/100 g body weight, which produced the same increase in pituitary GH in both groups of animals. These results seem to indicate that changes in pituitary GH content of neo-T4 rats are not due to hypothyroidism. Thus, it would appear that treatment with large T4 doses during the early perinatal period not only deranges the hypothalamic-pituitary-thyroid axis but other pituitary functions as well.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0001-5598
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
340-4
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis.
pubmed:publicationType
Journal Article