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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1983-12-20
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pubmed:abstractText |
Relapse of chronic T. brucei infections was completely prevented by treating with either diminazene aceturate (Berenil) at 40 mg/kg or suramin (Germanin) at 20 mg/kg followed by four doses of the 2-substituted 5-nitroimidazole (Fexinidazole) (Hoe 239). None of these drugs administered singly elicited 100% permanent cures although a high percentage of the mice were cured with four doses of Fexinidazole at 250 mg/kg. A single dose of 20 mg/kg suramin followed by four daily doses of 30 mg/kg Fexinidazole will effectively eliminate all the trypanosomes from the brains of chronically infected mice.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0044-3255
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
577-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6636983-Animals,
pubmed-meshheading:6636983-Antiprotozoal Agents,
pubmed-meshheading:6636983-Chronic Disease,
pubmed-meshheading:6636983-Diminazene,
pubmed-meshheading:6636983-Drug Therapy, Combination,
pubmed-meshheading:6636983-Female,
pubmed-meshheading:6636983-Mice,
pubmed-meshheading:6636983-Mice, Inbred Strains,
pubmed-meshheading:6636983-Nitroimidazoles,
pubmed-meshheading:6636983-Suramin,
pubmed-meshheading:6636983-Trypanocidal Agents,
pubmed-meshheading:6636983-Trypanosoma brucei brucei,
pubmed-meshheading:6636983-Trypanosomiasis, African
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pubmed:year |
1983
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pubmed:articleTitle |
The use of the 2 substituted 5-nitroimidazole, Fexinidazole (Hoe 239) in the treatment of chronic T. brucei infections in mice.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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