Linked Life Data

6634980

Source:http://linkedlifedata.com/resource/pubmed/id/6634980

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-12-17
pubmed:abstractText
We determined the serum levels of calcitonin (CT), calcium (Ca), and thyroxine (Ti) in lean (?/+) and fatty (fa/fa) male Zucker rats 10 weeks and 10-12 months of age. The most dramatic finding was a high level of serum CT (3.24 +/- 1.18 ng/ml) in young fatties whereas sera from young leans were all below the limit of assay detection (less than 0.120 ng/ml, p less than 0.01). Young fat rats also had elevated levels of both Ca (11.2 +/- 0.2 vs. 9.7 +/- 0.2 mg/dl, p less than 0.001) and Ti (6.7 +/- 0.48 vs. 4.72 +/- 0.28 micrograms/dl, p less than 0.01). In older animals the mean serum level of CT increased further in the fatties and became readily measurable in leans (5.67 +/- 1.94 vs. 1.49 +/- 0.55, p less than 0.01). Thyroid C-cells, identified immunohistochemically, were abundant in both leans and fatties at this age but were substantially more numerous in the fat rats (p less than 0.001). Calcium levels increased somewhat in the older leans, but still remained higher in the fat rats (p less than 0.05). Thyroxine values were essentially the same for old animals of both genotypes (5.07 +/- 0.61 vs. 5.54 +/- 0.88). Age effects were not significant for any measure in the fat animals, but in the leans there were significant age-related increases in CT (p less than 0.02) and serum Ca (p less than 0.05).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-84
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Serum calcitonin, calcium and thyroxine in young and old Zucker fatty rats (fa/fa).
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.