Linked Life Data

6630311

Source:http://linkedlifedata.com/resource/pubmed/id/6630311

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-12-17
pubmed:abstractText
Fibroblasts can adhere to extracellular matrix (ECM) material by fibronectin-dependent (type I) and fibronectin-independent (type II) mechanisms. In this report we investigate the biochemical characteristics of ECM that contribute to type II adhesion. ECM capable of mediating type II adhesions is produced primarily by normal diploid fibroblasts, but not by transformed cells or epithelial cells. Treatment of fibroblast ECM under conditions that result in the removal of most of the ECM lipid or most of the ECM glycosaminoglycan does not impair type II adhesion. Likewise, treatment of the ECM with large amounts of purified collagenase does not block type II adhesion. However, treatment of ECM with low doses of trypsin or with an agent that reacts with tyrosine residues, results in complete ablation of the ability of the ECM to support type II adhesion. On the basis of these observations we suggest that the matrix component(s) mediating type II adhesion are non-collagenous proteins or glycoproteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9533
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-301
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Fibronectin-independent adhesion of fibroblasts to extracellular matrix material: partial characterization of the matrix components.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.