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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1983-12-17
|
| pubmed:abstractText |
The synthesis and in vitro activity of 7 beta-[(Z)-2-alkoxyimino- 2-(2-aminothiazol-4-yl) acetamido]cephalosporins with a tetrazolo[1,5-b]pyridazine at the 3-position are described. These cephalosporins showed excellent activity against Gram-negative bacteria, including beta-lactamase producing strains. The most interesting compound of the series was 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetamido] -3-(8-carboxytetrazolo[1,5-b]pyridazin-6-yl)- thiomethyl-3-cephem-4-carboxylic acid (9, FCE 20485) because of its extraordinarily long half-life and marked in vivo activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1013-9
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:6630053-Cephalosporins,
pubmed-meshheading:6630053-Gram-Negative Bacteria,
pubmed-meshheading:6630053-Indicators and Reagents,
pubmed-meshheading:6630053-Magnetic Resonance Spectroscopy,
pubmed-meshheading:6630053-Microbial Sensitivity Tests,
pubmed-meshheading:6630053-Pyridazines,
pubmed-meshheading:6630053-Spectrophotometry, Infrared,
pubmed-meshheading:6630053-Structure-Activity Relationship,
pubmed-meshheading:6630053-Tetrazoles
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Cephalosporins. VI. Synthesis and structure-activity relationships of new 7 beta-[(Z)-2-alkoxyimino-2-(2-aminothiazol-4-yl)acetamido]cephalosporins with a tetraxolopyridazine at the 3-position.
|
| pubmed:publicationType |
Journal Article
|