Linked Life Data

6629546

Source:http://linkedlifedata.com/resource/pubmed/id/6629546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1983-12-17
pubmed:abstractText
The bioavailability of Theodel, a new scored tablet of theophylline, was investigated in eight healthy adult volunteers. Rate of absorption and AUC infinity were compared after single oral doses of Theodel (250 mg), of an aqueous solution (250 mg), and of two Theolair tablets (2 X 125 mg). Theophylline was rapidly absorbed from the Theodel tablet, with a t1/2abs of 0.44 +/- 0.37 h; maximum plasma concentrations of 8.0 +/- 2.3 mg/l were reached after 1.8 +/- 0.8 h. Almost the entire dose was recovered from urine as theophylline and its major metabolites, 1,3-dimethyluric acid, 1-methyluric acid, and 3-methylxanthine. Theophylline was, therefore, efficiently absorbed from this formulation. The plasma elimination half-life ranged from 5.9 to 10.4 h. Based on the assumption that absorption is complete, the plasma clearance ranged from 0.028 to 0.048 1 X h-1 X kg-1, and the apparent volume of distribution from 0.38 to 0.57 1/kg. No significant difference between the rate and the extent of theophylline absorption was observed for the three preparations, which are thus bioequivalent. Simulations of plasma levels after repeated administration of Theodel tablets showed that plasma theophylline concentrations remain in the therapeutic range with three doses per day.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0174-4879
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-30
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Bioavailability of Theodel, a new theophylline tablet, in humans.
pubmed:publicationType
Journal Article