Thiobenzamide (a thiono-sulfur-containing xenobiotic), when administered to male Sprague-Dawley rats primed with a single low dose of diethylnitrosamine, enhances the number and size of both gamma-glutamyltranspeptidase-positive hepatocellular foci and cholangiofibrotic areas. Its effect seems to be greater than that of the known promoter phenobarbital.
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