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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1983-12-20
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pubmed:abstractText |
Various plant viral RNAs possess a 3' terminus with tRNA-like properties. These viral RNAs are charged with an amino acid upon incubation with the cognate aminoacyl-tRNA synthetase and ATP. We have studied the structure of end-labelled 3'-terminal fragments of turnip yellow mosaic virus RNA and brome mosaic virus RNA 2 with chemical modifications of the adenosine and cytidine residues and with enzymatic digestions using RNase T1, nuclease S1 and the double-strand-specific ribonuclease from cobra venom. The data indicate that the 3' termini of these plant viral RNAs lack a cloverleaf structure as found in classical tRNA. The three-dimensional folding, however, reveals a striking resemblance with classical tRNA. The models proposed are supported by phylogenetic data. Apparently distinct three-dimensional solutions have evolved to meet the requirements for faithful recognition by tRNA-specific enzymes. The way in which the aminoacyl acceptor arms of these tRNA-like structures are constructed reveal novel features in RNA folding which may have a bearing on the secondary and tertiary structures of RNA in general. The dynamic behaviour of brome mosaic virus RNA 2 in solution presumably is illustrative of conformational transitions, which RNAs generally undergo on changing the ionic conditions.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-114514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-16453415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-387639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-402264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-4601792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-4602655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-60910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-6157105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-6159633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-6163133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-6176943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-6285419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-6291588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-7005687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-7079175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-7214524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-794835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-837924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-92011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6628363-978788
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1079-85
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Three-dimensional models of the tRNA-like 3' termini of some plant viral RNAs.
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pubmed:publicationType |
Journal Article,
Comparative Study
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